There's a bus every 5 minutes or so, which will get you in the hearth of the Histotical Center of Rome in 5 minutes.
As usual, get standard tickets in advance at tobaco shop or news paper stands, or get a Roma Pass.
Most of time, just get a 75 minutes (1,5 Euro ticket) per way and you'll be allright.

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Legenda

  • Orange: B&B Savoia
  • A: American Ambassade
  • B: Tritone Fountain
  • C: Spanish Steps
  • D: Trevi Fountain
  • E: Pantheon
  • F: Navona Square
  • G: Trajan's Market
  • H: Foro Romano
  • I: Colosseo
  • J: Campo de' Fiori
  • Red Polygon: Trastevere Neighbourhood (nice at night)

Location

Bus 80. Cheap, Easy and effective
Via Viterbo by the Mignon cinema
Roma, RM
Italy
41° 54' 42.0732" N, 12° 29' 53.5704" E